ChemicalBook CAS DataBase List 4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester

4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester synthesis

7synthesis methods

Product Name:4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester
CAS Number:40318-15-8
Molecular formula:C7H9NO2
Molecular Weight:139.15

623-43-8 Synthesis

623-43-8
198 suppliers
$11.00/10g

36635-61-7 Synthesis

36635-61-7
500 suppliers
$5.00/5g

4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester

40318-15-8
55 suppliers
$65.00/100mg

Yield:40318-15-8 25%

Reaction Conditions:

with potassium tert-butylate in tetrahydrofuran at 20; for 3.5 h;

Steps:

1 Methyl 4-methyl-1H-pyrrole-3-carboxylate

Reference Example 1 Methyl 4-methyl-1H-pyrrole-3-carboxylate To a suspension of potassium tert-butoxide (76.7 g) in tetrahydrofuran (900 mL) was added dropwise a solution of p-toluenesulfonylmethyl isocyanide (94.6 g) and methyl crotonate (48.5 g) in tetrahydrofuran (900 mL) over 30 min. The reaction mixture was stirred at room temperature for 3 hr, water was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent:hexane-ethyl acetate=4:1) to give the title compound as a white solid (yield 16.8 g, 25%). ¹H-NMR (CDCl₃) δ: 2.29 (3H, s), 3.80 (3H, s), 6.53-6.54 (1H, m), 7.36-7.38 (1H, m), 8.25 (1H, brs).

References:

EP2005957,2008,A1 Location in patent:Page/Page column 44

2199-49-7 Synthesis