4-METHOXYPHENYL ISOTHIOCYANATE synthesis
- Product Name:4-METHOXYPHENYL ISOTHIOCYANATE
- CAS Number:2284-20-0
- Molecular formula:C8H7NOS
- Molecular Weight:165.21
75-15-0
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104-94-9
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2284-20-0
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$12.00/1g
Yield:2284-20-0 96%
Reaction Conditions:
Stage #1:carbon disulfide;4-methoxy-aniline with triethylamine in ethanol at 20; for 1 h;
Stage #2: with dmap;di-tert-butyl dicarbonate at 0 - 20; for 4 h;
Steps:
The synthesis of 1-isothiocyanato-4-methoxybenzene (SF9)
General procedure: The solution of 3-(2-aminoethyl)indole (80.1 mg, 0.5 mmol) in EtOH (1 mL, 0.5 M) was treated with carbon disulfide (114.2 mg, 1.5 mmol) followed by triethylamine (50.6 mg, 0.5 mmol). After stirring at room temperature for 1 hour, Boc2O (109.1 mg, 0.5 mmol) and DMAP (1.8 mg, 0.015 mmol) was added to the reaction mixture at 0 °C. The reaction was stirred at room temperature for 2 hours and leave it additionally 2 hour to remove SCO gas. After the reaction completes, the crude product was extracted with ethyl acetate (50 mL) and purified by silica gel chromatography to afford 3-(2-isothiocyanatoethyl)-1H-indole (89.9 mg, 89%).
References:
Kim, Taejung;Kim, Young-Joo;Han, Im-Ho;Lee, Dahae;Ham, Jungyeob;Kang, Ki Sung;Lee, Jae Wook [Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,# 1,p. 62 - 66] Location in patent:supporting information
38435-51-7
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2284-20-0
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$12.00/1g
4968-41-6
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2284-20-0
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10349-38-9
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$31.00/100mg
2284-20-0
138 suppliers
$12.00/1g