(4'-METHOXYBIPHENYL-4-YL)-METHANOL synthesis
- Product Name:(4'-METHOXYBIPHENYL-4-YL)-METHANOL
- CAS Number:20854-60-8
- Molecular formula:C14H14O2
- Molecular Weight:214.26
729-17-9
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$55.00/100mg
20854-60-8
26 suppliers
$275.00/1g
Yield:20854-60-8 99%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 2 h;
Steps:
Synthesis of intermediate 15
The carboxylic acid methyl ester derivative 14 (2.00 g, 8.25 mmol, 1.0 eqiuv.) was dissolved in THF (dry) (20 mL) and the solution was cooled to 0°C. To the solution 2.4M LiAliL/THF (4.5 mL, 10.70 mmol, 1.3 equiv.) was added dropwise and stirring was continued at r.t. for 2h. The reaction mixture was cooled to 0°C and H20 (0.4 mL) was added and stirred for 5 min, then 4N NaOH sol. (0.8 mL) was added and stirred for 10 min, after that H20 (1.2 mL) was added and stirred for 10 min. Precipitate was filtered off and filtrate was evaporated, giving the desired product 15 (1.76 g, 99%).
References:
WO2017/69601,2017,A1 Location in patent:Page/Page column 21
18282-51-4
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33397-21-6
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$172.00/50MG
20854-60-8
26 suppliers
$275.00/1g
623-12-1
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$10.00/25g
59016-93-2
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$5.00/1g
20854-60-8
26 suppliers
$275.00/1g
5720-07-0
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$6.00/5g
873-76-7
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$6.00/10g
20854-60-8
26 suppliers
$275.00/1g
