4-Hydroxy-8-methoxycinnoline synthesis
- Product Name:4-Hydroxy-8-methoxycinnoline
- CAS Number:90417-27-9
- Molecular formula:C9H8N2O2
- Molecular Weight:176.17
42465-54-3
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Yield:-
Reaction Conditions:
with hydrogenchloride;sodium acetate;sodium nitrite in water;
Steps:
5 4-hydroxy-8-methoxycinnoline (5)
3.30 g of 5B was suspended in a mixture of 20 ml of water, 20 g of ice and 4.5 ml of concentrated hydrochloric acid. Then, at 0° C., a solution of 1.45 g of sodium nitrite in 10 ml of water was added. After 25 minutes, 40 ml of chilled methylene chloride and a solution of 16.40 g of sodium acetate in 40 ml of water was added. The resulting mixture was stirred at about 12° C. overnight and filtered. The filtrate was dried under reduced pressure, then the solvent was evaporated to give 5, as a brown solid, m.p.: 160°-163° C.
References:
US4620000,1986,A
3177-80-8
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