4-Hydroxy-3-methoxymandelic acid synthesis
- Product Name:4-Hydroxy-3-methoxymandelic acid
- CAS Number:55-10-7
- Molecular formula:C9H10O5
- Molecular Weight:198.17
Yield:55-10-7 95.7%
Reaction Conditions:
with C38H58Cl2CrN3O2;sodium hydroxide in water; pH=11 at 28; for 1.5 h;Catalytic behavior;pH-value;Reagent/catalyst;Temperature;
Steps:
1-26 Example 14:
Take 124g (1mol) of guaiacol dissolved in 900g (50mol) of water, 0.711 g of a SalenCrCl complex having a quaternary ammonium salt cation attached to a ligand represented by formula (II) is added as a catalyst, Stir well, Slowly add 40% by weight aqueous sodium hydroxide solution to adjust the pH to 11, Adjust the system temperature to 28 ° C, Then, 75 g of an aqueous glyoxylic acid solution (containing 0.5 mol of glyoxylic acid) and a 40 wt% aqueous sodium hydroxide solution were added dropwise at the same time. After 1h dripping, Control the pH to stabilize at 11. Reaction aging 0.5h, Sampling analysis. Glyoxylic acid conversion rate is 95%, The selectivity of the counter product is 98%. Production of 3-methoxy-4-hydroxymandelic acid product Confirmation as in the first embodiment
References:
Wanhua Chemical Group Co., Ltd.;Fu Song;Li Junping;Chen Haibo;Wang Rui;Cao Shanjian;Liu Zhikun;Li Yuan CN109956858, 2019, A Location in patent:Paragraph 0081-0145
62-76-0
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121-33-5
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55-10-7
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$19.00/250mg
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55-10-7
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