4-HYDROXY-2-OXO-2H-CHROMENE-3-CARBALDEHYDE synthesis
- Product Name:4-HYDROXY-2-OXO-2H-CHROMENE-3-CARBALDEHYDE
- CAS Number:51751-34-9
- Molecular formula:C10H6O4
- Molecular Weight:190.15
1076-38-6
550 suppliers
$24.00/100 g
100-97-0
0 suppliers
$14.00/250G
51751-34-9
30 suppliers
$65.00/100mg
Yield: 65%
Reaction Conditions:
Stage #1:4-hydroxy[1]benzopyran-2-one;hexamethylenetetramine with trifluoroacetic acid for 0.05 h;Microwave irradiation;
Stage #2: with sulfuric acid for 0.5 h;Reflux;
Steps:
Synthesis of 4-hydroxy-2-oxo-2H-chromene-3- carbaldehyde (1).
4-Hydroxycoumarin (1 mmol) and hexamethylenetetramine (HMTA) (3 mmol) was dissolved in 10 ml of trifl uoroacetic acid and subjected to microwave irradiation at 800 W for 3 min with gentle stirring. The reaction progress was monitored by TLC. After completion of the reaction, the reaction mixture was treated with 50% v/v hot solution of sulfuric acid solution and then refl uxed for 30 min. The product was extracted with ethyl acetate, and the extract was evaporated to leave compound 1, yield 65%, mp 139.2°C (135-140°C [38]).
References:
Karteek, S. Durga;Reddy, A. Gopi;Tej, M. Bhuvan;Rao, M. V. Basaveswara [Russian Journal of Organic Chemistry,2021,vol. 57,# 2,p. 272 - 282][Zh. Org. Khim.]
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
51751-34-9
30 suppliers
$65.00/100mg
1189755-26-7
0 suppliers
inquiry
51751-34-9
30 suppliers
$65.00/100mg
52817-14-8
0 suppliers
inquiry
51751-34-9
30 suppliers
$65.00/100mg
1076-38-6
550 suppliers
$24.00/100 g
122-51-0
502 suppliers
$10.00/5ml
51751-34-9
30 suppliers
$65.00/100mg