4-ETHYL ISATIN synthesis

4synthesis methods

Product Name:4-ETHYL ISATIN
CAS Number:34934-05-9
Molecular formula:C10H9NO2
Molecular Weight:175.18

N-((3-ETHYLPHENYL)-2-HYDROXYIMINO)-ACETAMIDE

34934-04-8
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90924-07-5 Synthesis

90924-07-5
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34934-05-9
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Yield:34934-05-9 34%

Reaction Conditions:

with sulfuric acid;water at 50 - 80; for 0.166667 h;

Steps:

5

The isonitrosoacetanilide (10.0 g, 0.05 mol), was added portionwise to a mixture of water (9 ml) and conc. sulphuric acid (60 ml) prewarmed to 50°C, maintaining the temperature between 50-55 °C. When the addition was completed, the mixture was heated to 80°C and kept at this temperature for 10 minutes. The reaction mixture was then cooled on an ice-bath and poured on 10-12 times the reaction volume of crushed ice. The mixture was then left standing for about one hour. The water suspension was extracted with dichloromethane which was dried and evaporated resulting in an mixture of the two analogues 4-ethyl and 6-ethyl isatins approximately 0.68:1 (7.6 g), yield 84%.

References:

EP1095021,2003,B1 Location in patent:Page/Page column 7