4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE synthesis
- Product Name:4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE
- CAS Number:681260-56-0
- Molecular formula:C12H6ClFN2S
- Molecular Weight:264.71
403-42-9
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681260-56-0
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Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: trichlorophosphate; N,N-dimethyl-formamide / N,N-dimethyl-formamide
2.1: sodium methylate / methanol / 1 h
2.2: 5 h / 60 °C
3.1: 18 h / 180 °C
4.1: trichlorophosphate; N,N-dimethyl-formamide / 6 h / 110 °C
References:
Romagnoli, Romeo;Prencipe, Filippo;Oliva, Paola;Baraldi, Stefania;Baraldi, Pier Giovanni;Schiaffino Ortega, Santiago;Chayah, Mariem;Kimatrai Salvador, Maria;Lopez-Cara, Luisa Carlota;Brancale, Andrea;Ferla, Salvatore;Hamel, Ernest;Ronca, Roberto;Bortolozzi, Roberta;Mariotto, Elena;Mattiuzzo, Elena;Viola, Giampietro [Journal of Medicinal Chemistry,2019,vol. 62,# 3,p. 1274 - 1290]
![6-(4-FLUOROPHENYL)-3,4-DIHYDROTHIENO[3,2-D]-PYRIMIDIN-4-ONE](/StructureFile/ChemBookStructure2/GIF/CB7173378.gif)
215928-68-0
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681260-56-0
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