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55496-54-3

4-CHLORO-5,6,7-TRIMETHOXYQUINAZOLINE synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: H2 / Pd/C / methanol / 17 h
2: piperidine / methanol / 2.5 h / 65 °C
3: 51 percent / POCl3, diisopropylethylamine / 1,2-dichloro-ethane / 1.5 h / 80 °C

References:

Bridges;Zhou;Cody;Rewcastle;McMichael;Showalter;Fry;Kraker;Denny [Journal of Medicinal Chemistry,1996,vol. 39,# 1,p. 267 - 276]