4-CHLORO-5-(4-FLUOROPHENYL)THIENO[2,3-D]PYRIMIDINE synthesis
- Product Name:4-CHLORO-5-(4-FLUOROPHENYL)THIENO[2,3-D]PYRIMIDINE
- CAS Number:384351-45-5
- Molecular formula:C12H6ClFN2S
- Molecular Weight:264.71
![5-(4-FLUOROPHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE](/CAS/GIF/35978-37-1.gif)
35978-37-1
37 suppliers
$85.00/250mg
384351-45-5
28 suppliers
$115.00/500mg
Yield:384351-45-5 80%
Reaction Conditions:
with phosphorus pentachloride;trichlorophosphate at 105;
Steps:
2.3.4 Substituted 4-chloro-thieno[2,3-d]pyrimidines (iv)
General procedure: A mixture of thienopyrimidinone (0.01 mol), POCl3 (11 mL) and PCl5 (1.5 g) was quickly heated to 105° C and boiled for 5-6 h. The solvent was evaporated. Dry product was dissolved in methylene chloride (12 mL) and neutralized by cold solution of NaOH (0.5 N). The organic phase was separated and dried over Na2SO4, filtered, and then solvent was evaporated in vacuum. The residue was crystallized from isopropyl alcohol. Yield 80%
References:
Ostrynska, Olga V.;Balanda, Anatoliy O.;Bdzhola, Volodymyr G.;Golub, Andriy G.;Kotey, Igor M.;Kukharenko, Olexander P.;Gryshchenko, Andrii A.;Briukhovetska, Nadiia V.;Yarmoluk, Sergiy M. [European Journal of Medicinal Chemistry,2016,vol. 115,p. 148 - 160]
403-42-9
546 suppliers
$5.00/10g
384351-45-5
28 suppliers
$115.00/500mg
![Propanedinitrile, 2-[1-(4-fluorophenyl)ethylidene]-](/CAS/20200331/GIF/579-48-6.gif)
579-48-6
1 suppliers
inquiry
384351-45-5
28 suppliers
$115.00/500mg
35978-33-7
70 suppliers
$28.60/50MG
384351-45-5
28 suppliers
$115.00/500mg
519016-84-3
2 suppliers
inquiry
384351-45-5
28 suppliers
$115.00/500mg