(4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID synthesis
- Product Name:(4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID
- CAS Number:588-20-5
- Molecular formula:C9H9ClO3
- Molecular Weight:200.62
30406-61-2
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588-20-5
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$57.50/250mg
Yield:588-20-5 77%
Reaction Conditions:
with sodium hydroxide in ethanol;water;Reflux;
Steps:
3 4.1.2.1 General synthetic procedure for phenoxyacetic acid analogues (4a-j)
General procedure: Compounds (3a-j,0.02mol) were dissolved in ethanol (15mL), sodium hydroxide (0.035mol) in water (5mL) was added, and the mixture was refluxed for 5-9h. The reaction mixture was cooled and acidified with 2N hydrochloric acid. The precipitate was filtered, washed with water, and finally recrystallized from methanol to afford desired compounds (4a-j). Compound (4a) is takenas a representative example to explain physical and characterization data.
References:
Mohammed, Yasser Hussein Eissa;Malojirao, Vikas H.;Thirusangu, Prabhu;Al-Ghorbani, Mohammed;Prabhakar;Khanum, Shaukath Ara [European Journal of Medicinal Chemistry,2018,vol. 143,p. 1826 - 1839]
59-50-7
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588-20-5
31 suppliers
$57.50/250mg
1643-15-8
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$14.00/500mg
588-20-5
31 suppliers
$57.50/250mg