Yield:-

Reaction Conditions:

with water;hydrogen bromide;acetic acid in water; for 24 h;Heating / reflux;

Steps:

1.iii

Ui) (4-Chloro-3-hydroxyphenyI)acetic acidThe product from step (ii) (12.2 g), HBr (48 % aq.) and acetic acid (10 ml) were charged to a flask and heated at reflux for 24 h, cooled then evaporated under reduced pressure. The EPO residue was triturated with ether/isohexane, and then filtered to give the subtitle compound(10.6 g).'HNMRCDCls-d: δ 7.32 (IH, d), 6.85 (IH, s), 6.82 (IH, d), 3.9 (3H, s), 3.63 (2H, s).

References:

WO2007/39736,2007,A1 Location in patent:Page/Page column 28-29