Yield:-

Reaction Conditions:

with trichlorophosphate

Steps:

17.3 Step 3

Step 3 6-iodo-2-trifluoromethyl-4-chloroquinazoline 6-iodo-2-trifluoromethyl-3H-quinazolin-4-one (3.1 g, 9.1 mmole) was mixed with 20 mL of POCl₃, heated to reflux for 3 h, removed most of unreacted POCl₃ under vacuo. The residue was extracted with 15 mL of NaHCO₃ (sat) and 200 mL of ether, ether layer was dried with MgSO₄ and concentrated to give the light yellow solid 3.05 g, mp 145°-146° C., MS (CI): m/z 359 (MH)⁺.

References:

US5658902,1997,A