4'-chloro-2'-methoxypropiophenone synthesis

7synthesis methods

Product Name:4'-chloro-2'-methoxypropiophenone
CAS Number:36871-55-3
Molecular formula:C10H11ClO2
Molecular Weight:198.65

Preparation by reaction of dimethyl sulfate with 4-chloro-2-hydroxypropiophenone in the presence of sodium hydroxide.

4-chloro-N,2-dimethoxy-N-methylbenzamide

205320-02-1
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$199.91/1g

925-90-6 Synthesis

925-90-6
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$12.00/5ml

36871-55-3
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$79.00/1g

Yield:-

Reaction Conditions:

in tetrahydrofuran;diethyl ether at -78 - 20; for 16 h;

References:

Lynch, John K.;Freeman, Jennifer C.;Judd, Andrew S.;Iyengar, Rajesh;Mulhern, Mathew;Zhao, Gang;Napier, James J.;Wodka, Dariusz;Brodjian, Sevan;Dayton, Brian D.;Falls, Doug;Ogiela, Christopher;Reilly, Regina M.;Campbell, Thomas J.;Polakowski, James S.;Hernandez, Lisa;Marsh, Kennan C.;Shapiro, Robin;Knourek-Segel, Victoria;Droz, Brian;Bush, Eugene;Brune, Michael;Preusser, Lee C.;Fryer, Ryan M.;Reinhart, Glenn A.;Houseman, Kathryn;Diaz, Gilbert;Mikhail, Ann;Limberis, James T.;Sham, Hing L.;Collins, Christine A.;Kym, Philip R. [Journal of Medicinal Chemistry,2006,vol. 49,# 22,p. 6569 - 6584]