4-CHLORO-2,6-DIFLUOROBENZYL ALCOHOL synthesis
- Product Name:4-CHLORO-2,6-DIFLUOROBENZYL ALCOHOL
- CAS Number:288154-93-8
- Molecular formula:C7H5ClF2O
- Molecular Weight:178.56
128800-36-2
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288154-93-8
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$28.60/25MG
Yield:288154-93-8 85.2%
Reaction Conditions:
Stage #1: 2-Chloro-4,5-difluorobenzoic acid methyl esterwith lithium aluminium tetrahydride in tetrahydrofuran at 20; for 4 h;
Stage #2: with water;sodium sulfate in tetrahydrofuran; for 0.5 h;
Steps:
14.2
Step 2 Preparation of (2 chloro-4 5-dιfluoro-phenyl)-methanol (120) [0181] To 2-chloro-4,5-difluoro-benzoic acid methyl ester (119, 5 70 g, 0 0276 mol) in lelrahydrofuran ( 120 0 mL), 1 00 M of lithium tetrahydroalummate in tetrahydrofuran (30 0 mL) was added slowly under an atmosphere of nitrogen The reaction was stirred at room temperature for 4 hours, followed by adding sodium sulfate decahydrate After 30 minutes, the reaction mixture was
References:
WO2008/80001,2008,A2 Location in patent:Page/Page column 76-77
110877-64-0
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288154-93-8
26 suppliers
$28.60/25MG