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ChemicalBook CAS DataBase List 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE
2770-01-6

4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE synthesis

14synthesis methods
-

Yield:2770-01-6 98%

Reaction Conditions:

with hydrogenchloride in water at 20;Inert atmosphere;

Steps:

22.1 Step 1: Preparation of 4-chloro-1H-imidazo[4,5-c]pyridine (intermediate S1-1)
2-chloro-3,4-diaminopyridine (2.87 g, 20 mmol) and trimethyl orthoformate (40 mL) were added into a round-bottom flask, and concentrated hydrochloric acid (3 mL) was slowly added dropwise at room temperature, the mixture solution was stirred overnight at room temperature.
A large number of solids were precipitated and filtered out, and the filter cake was washed with petroleum ether and dried to obtain the crude product of 4-chloro-1H-imidazo[4,5-c]pyridine (3.7 g, yield 98%). MS m/z (ESI): 154 [M+H]+.

References:

Abbisko Therapeutics Co., Ltd.;ZHANG, Mingming;ZHAO, Baowei;YU, Hongping;CHEN, Zhui;XU, Yaochang US2020/140431, 2020, A1 Location in patent:Paragraph 0166; 0211-0213

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