4-BROMOPYRIDINE-2-CARBALDEHYDE synthesis
- Product Name:4-BROMOPYRIDINE-2-CARBALDEHYDE
- CAS Number:131747-63-2
- Molecular formula:C6H4BrNO
- Molecular Weight:186.01
131747-45-0
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131747-63-2
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Yield:131747-63-2 100%
Reaction Conditions:
with manganese(IV) oxide in chloroform for 0.75 h;Reflux;
Steps:
29.i 4-Bromopicolinaldehyde
Example 29i 4-Bromopicolinaldehyde Manganese(IV) oxide (22.19 g, 255.29 mmol) was added to a solution of (4-bromopyridin-2-yl)methanol (4.00 g, 21.27 mmol) in chloroform (80 mL) and the reaction mixture was stirred under reflux for 45 min. After the mixture had cooled to room temperature the solids were removed by filtration through a pad of Celite. The solvent was removed in vacuo and the residue (3.96 g, quant.) was used without further purification in the next step. 1H NMR (500 MHz, DMSO-d6) δ ppm 9.97 (s, 1H) 8.80 (d, 1H) 7.98 (d, 1H) 7.88 (dd, 1 H); MS (APCI+): m/z 186, 188 [M+H]+.
References:
ASTRAZENECA AB US2010/125082, 2010, A1 Location in patent:Page/Page column 24
1005342-94-8
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1885-14-9
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22282-99-1
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131747-63-2
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108338-19-8
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131747-63-2
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