ChemicalBook CAS DataBase List 4-Bromo-2,5-dimethoxybenzaldehyde

4-Bromo-2,5-dimethoxybenzaldehyde synthesis

5synthesis methods

Product Name:4-Bromo-2,5-dimethoxybenzaldehyde
CAS Number:31558-41-5
Molecular formula:C9H9BrO3
Molecular Weight:245.07

25245-34-5 Synthesis

25245-34-5
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31558-41-5
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Yield:31558-41-5 87%

Reaction Conditions:

with titanium tetrachloride in dichloromethane at -78; for 1 h;

Steps:

1
2,5-Dimethoxybromobenzene (5) (7.0 ml :47 mmol) was dissolved in 160 ml of dichloromethane. The solution was added with 13 ml (0.12 mol) of titanium chloride (IV) under argon atmosphere at -78°C, subsequently with 8.2 ml (0.14 mol ) of dichloromethylmethy ether, and stirred at -78°C for one hour. The reaction mixture was gradually added to 600 ml of ice water and extracted with dichloromethane. The dichloromethane layer was washed with an aqueous saturated sodium hydrogencarbonate solution, water, and saturated brine, and then dried over sodium sulfate. The dichloromethane was evaporated under reduced pressure, and the residue was purified by silica gel column to obtain 9.9 g of Compound (6) (yield 87 %).1H-NMR (CDCl3, 300 MHz): 10.40 (s, 1H), 7.34 (s, 1H), 7.25 (s, 1H), 3.91 (s, 3H), 3.90 (s, 3H)

References:

Daiichi Pure Chemicals Co. Ltd.;Nagano, Tetsuo EP1403268, 2004, A1 Location in patent:Page 10

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93-02-7 Synthesis