4-(BENZYLOXY)-2-METHYLPHENOL synthesis
- Product Name:4-(BENZYLOXY)-2-METHYLPHENOL
- CAS Number:53325-49-8
- Molecular formula:C14H14O2
- Molecular Weight:214.26
![Benzene, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methyl-4-(phenylmethoxy)-](/CAS/20210305/GIF/936711-78-3.gif)
936711-78-3
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53325-49-8
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Yield:53325-49-8 93%
Reaction Conditions:
with tetrabutyl ammonium fluoride in tetrahydrofuran at 20; for 4 h;
Steps:
16.D
Step D; (4-Benzyloxy-2-methyl-phenoxy)-ter/-butyl-dimethyl-silane 12 (5.03 g, 15.3 mmol) is dissolved in 30 mL THF. A 1.0 M solution of tetra-(?-butyl)ammonium fluoride in THF (18 mL, 18 mmol, 1.5 equiv.) is added; the mixture is stirred at room temperature for 4h. Concentration to dryness and purification by silica gel chromatography (10-30% gradient, ethyl acetate in hexanes) yielded 4-benzyloxy-2-methyl-phenol 13 (3.06 g, 14.3 mmol, 93%). 1H-NMR (400 MHz, CDCl3) δ = 7.42 (m, 4H), 7.31 (m, IH), 6.78 (s, IH), 6.69 (s, 2H), 4.99 (s, 2H), 2.27 (s, 3H).
References:
WO2007/56496,2007,A1 Location in patent:Page/Page column 26
95-71-6
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100927-02-4
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53325-49-8
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91126-02-2
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![Benzoic acid, 2-[(ethoxycarbonyl)oxy]-5-(phenylmethoxy)-, anhydride with ethyl hydrogen carbonate (9CI)](/CAS/20240320/GIF/835613-29-1.gif)
835613-29-1
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53325-49-8
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2444-22-6
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53325-49-8
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95-71-6
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53325-49-8
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$155.00/100mg