4-(4-FLUORO-PHENYL)-PIPERIDIN-4-OL HYDROCHLORIDE synthesis
- Product Name:4-(4-FLUORO-PHENYL)-PIPERIDIN-4-OL HYDROCHLORIDE
- CAS Number:3888-65-1
- Molecular formula:C11H14FNO
- Molecular Weight:195.23
163631-02-5
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3888-65-1
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Yield: 82%
Reaction Conditions:
with 10 wt% Pd(OH)2 on carbon;hydrogen in methanol
Steps:
I.1.12.2
To a solution of Compound 2 (0.9 g, 3.1 mmol) in MeOH was added Pd(OH)2/C (100 mg), and the formed mixture was stirred under H2 balloon overnight. The Pd was filtered and the filtrate was concentrated to give the desired product (0.5 g, 82 %). LCMS: 196.2 [M+l].
References:
NOVIRA THERAPEUTICS, INC.;HARTMAN, George D.;FLORES, Osvaldo A. WO2013/96744, 2013, A1 Location in patent:Page/Page column 213
553631-05-3
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3888-65-1
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82387-58-4
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352-13-6
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3888-65-1
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29976-53-2
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3888-65-1
68 suppliers
$29.39/250mg