ChemicalBook CAS DataBase List 4,4'-DIFLUOROBENZIL

4,4'-DIFLUOROBENZIL synthesis

12synthesis methods

Product Name:4,4'-DIFLUOROBENZIL
CAS Number:579-39-5
Molecular formula:C14H8F2O2
Molecular Weight:246.21

1,2-Ethanediol, 1,2-bis(4-fluorophenyl)-

24133-58-2
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579-39-5
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Yield:579-39-5 78%

Reaction Conditions:

with 1-butyl-3-methylimidazolium hydrogen sulfate;sodium bromate in water at 60; for 0.833333 h;Green chemistry;

Steps:

General procedure for the oxidation of 1,2-diols, a-hydroxyketones and alcohols to 1,2-diketones and aldehydes/ketones

General procedure: In a typical experiment, a mixture of 1,2-diols/a-hydroxyketones/alcohols (1 mmol), sodium bromate (3 mmol),and bmim[HSO4]:H2O 3:1 (v/v) along with a stir bar was placed in a RB flask fitted with a condenser. The reaction mixture was stirred magnetically in an oil-bath maintained at 60 C for an appropriate time as mentioned in Tables 3,4, and 5, respectively. After completion of the reaction, as monitored by TLC using petroleum ether:ethyl acetate(80:20, v/v) as eluent, the reaction mixture was cooled to room temperature and worked up as mentioned above. The product obtained was identified by m.p (wherever applicable), IR and NMR spectra.

References:

Khurana, Jitender M.;Lumb, Anshika;Chaudhary, Ankita [Monatshefte fur Chemie,2017,vol. 148,# 2,p. 381 - 386]