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ChemicalBook CAS DataBase List 4-(4-Aminophenyl)-3-methyl-4-oxobutanoic acid
42075-29-6

4-(4-Aminophenyl)-3-methyl-4-oxobutanoic acid synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 6 steps
1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 34 h / 26 °C / Large scale
2: sodium ethanolate / N,N-dimethyl-formamide / 15.5 h / -5 - 0 °C / Large scale
3: ethanol / 16 h / 52 °C / Large scale
4: sodium ethanolate / N,N-dimethyl-formamide / 14 h / 16 °C / Large scale
5: sodium hydroxide / ethanol / 28 h / 67 °C / Large scale
6: hydrogen / ethanol / 22 h / 58 °C / 1520.1 Torr / Large scale

References:

AstaTech?(Chengdu) Biopharmaceutical?Co.,?Ltd;WEI, GENGHUI;LIU, WEIGUO;LUO, JIANYE;GUO, PENG CN104496834, 2016, B

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