4-(2-piperidinoethoxy)aniline synthesis

12synthesis methods

Product Name:4-(2-piperidinoethoxy)aniline
CAS Number:38948-27-5
Molecular formula:C13H20N2O
Molecular Weight:220.31

92033-76-6 Synthesis

92033-76-6
11 suppliers
$131.00/5g

38948-27-5
30 suppliers
$65.00/100mg

Yield:38948-27-5 100%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol; under 2068.65 Torr; for 0.5 h;

Steps:

14.C

C. 4-(2-Piperidin-1-yl-ethoxy)-phenylamine. To a solution of 1-[2-(4-nitro-phenoxy)-ethyl]-piperidine (300 mg, 1.20 mmol) in EtOH (50 mL) was added 10% Pd/C (50 mg). The mixture was placed on a Parr hydrogenator at 40 psi of H₂ for 30 min. The resultant mixture was filtered through diatomaceous earth, and the filtrate was concentrated to give a clear and colorless oil (264 mg, 100%). ¹H NMR (400 MHz, DMSO-d₆): 6.64 (d, J=8.7, 2H), 6.50 (d, J=8.0, 2H), 4.58 (s, 2H), 3.90 (t, J=6.0, 2H), 2.57 (t, J=6.0, 2H), 2.39 (s, 4H), 1.52-1.44 (m, 4H), 1.41-1.34 (m, 2H).

References:

US2006/223792,2006,A1 Location in patent:Page/Page column 27