2-(chloromethyl)-5-(2-methylphenyl)-1,3,4-oxadiazole synthesis
- Product Name:2-(chloromethyl)-5-(2-methylphenyl)-1,3,4-oxadiazole
- CAS Number:36770-20-4
- Molecular formula:
- Molecular Weight:0
Yield:36770-20-4 70%
Reaction Conditions:
with trichlorophosphate for 6 h;Reflux;
Steps:
2. General experimental procedure for synthesis of compound 7
General procedure: A mixture of aryl acid hydrazide (10mmol), chloroacetic acid (10mmol) and POCl3 (7mL) was heated under reflux for 6h. The excess POCl3 was removed under reduced pressure and the residue was poured onto crushed ice. The resuting precipitate was filtered, washed with saturated sodium bicarbonate solution and then with water, dried and recrystallized from ethanol/water to afford compound 7.
References:
Zhang, Kai;Wang, Peng;Xuan, Li-Na;Fu, Xiao-Yun;Jing, Fen;Li, Sha;Liu, Yu-Ming;Chen, Bao-Quan [Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,# 22,p. 5154 - 5156] Location in patent:supporting information
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