3-(Trifluoromethyl)benzyl bromide synthesis
- Product Name:3-(Trifluoromethyl)benzyl bromide
- CAS Number:402-23-3
- Molecular formula:C8H6BrF3
- Molecular Weight:239.03
349-75-7
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402-23-3
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Yield:402-23-3 67%
Reaction Conditions:
with phosphorus tribromide in dichloromethane;water at 10;
Steps:
202.2
A solution of (3-Trifluoromethyl-phenyl)-methanol (180 g, 1.0 mol, 1.0 eqiv.) in dichloromethane (1000 mL) was cooled below 10° C. and phosphorus tribromide (360 g, 1.30 mol, 1.3 eqiv.) was added dropwise in 30 minutes. The mixture was stirred overnight and water was added dropwise until no gas was produced. The solution was washed with saturated sodium hydrogen carbonate (2×500 mL) and water (200 mL). The organic layer dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as an brown-red liquid (163 g, 67%).
References:
Kalypsys, Inc. US2005/234046, 2005, A1 Location in patent:Page/Page column 97
454-89-7
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402-23-3
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401-79-6
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402-23-3
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402-26-6
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402-23-3
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$6.00/1g