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ChemicalBook CAS DataBase List 3(R)-HYDROXYMETHYLMORPHOLINE
211053-49-5

3(R)-HYDROXYMETHYLMORPHOLINE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: dimethylsulfide borane complex; triethylamine / tetrahydrofuran / 5 h / 0 - 65 °C
2: hydrogen; palladium 10% on activated carbon / methanol / 48 h / 2100.21 Torr

References:

Borsari, Chiara;Rageot, Denise;Dall'Asen, Alix;Bohnacker, Thomas;Melone, Anna;Sele, Alexander M.;Jackson, Eileen;Langlois, Jean-Baptiste;Beaufils, Florent;Hebeisen, Paul;Fabbro, Doriano;Hillmann, Petra;Wymann, Matthias P. [Journal of Medicinal Chemistry,2019,vol. 62,# 18,p. 8609 - 8630]

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