ChemicalBook CAS DataBase List 3-Ethoxypropylamine

3-Ethoxypropylamine synthesis

3synthesis methods

Product Name:3-Ethoxypropylamine
CAS Number:6291-85-6
Molecular formula:C5H13NO
Molecular Weight:103.16

2141-62-0
136 suppliers
$8.00/25g

6291-85-6
195 suppliers
$23.00/25mL

Yield:6291-85-6 92%

Reaction Conditions:

with ammonia;hydrogen;potassium hydroxide at 85; under 750.075 - 27002.7 Torr; for 5 h;Autoclave;Reagent/catalyst;Temperature;

Steps:

1; 2; 3

20 g of catalyst Raney nickel was added to 100 g of 0.5% potassium hydroxide solution and stirred for two hours.Then, the supernatant liquid was decanted, and the obtained catalyst was washed twice with 100 ml of ionized water to obtain a modified Raney nickel catalyst B.The obtained catalyst B and the 3-ethoxypropionitrile obtained in the above step were added to the autoclave.After replacing the nitrogen gas with 0.1 MPa, 0.2 MPa, and 0.3 MPa for 3 times, and then replacing the hydrogen gas with 0.1 MPa, 0.2 MPa, and 0.3 MPa for 3 times,80g into the liquid ammonia, heated to 85 degrees, into the hydrogen, the hydrogenation under a pressure of 3.6Mpa, basically do not eat hydrogen after 5 hours,Sampling, GC analysis: 3-ethoxypropionitrile 0.02%, 3-ethoxypropylamine 94.6%.It is then cooled and the inhibitor liquid ammonia is removed to another autoclave which can be applied to the next batch.Then, it was allowed to stand, filtered, and rectified to obtain 375 g of 99.7% of 3-ethoxypropylamine.The yield was 92%.

References:

CN109369423,2019,A Location in patent:Paragraph 0016; 0020-0025

64-17-5 Synthesis