3-BROMO-2-FLUOROBENZOIC ACID ETHYL ESTER synthesis
- Product Name:3-BROMO-2-FLUOROBENZOIC ACID ETHYL ESTER
- CAS Number:334792-76-6
- Molecular formula:C9H8BrFO2
- Molecular Weight:247.06
64-17-5
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161957-56-8
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334792-76-6
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Yield:334792-76-6 92%
Reaction Conditions:
with sulfuric acid at 20; for 24 h;Reflux;
Steps:
1 Ethyl 3-bromo-2-fluorobenzoate (2)
To a stirred solution of 3-bromo-2-fluorobenzoic acid 1 (25.0 g, 114.15 mmol) in ethanol (400 mL) was added conc. H2S04 (3 mL) at RT and stirred at reflux temperature for 24 h. The reaction was monitored by LC-MS; after completion of the reaction, the reaction mixture was concentrated to obtain the residue. The residue was diluted with EtOAc (500 mL), washed with water (300 mL), brine (300 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to afford compound 2 (26.0 g, 92%) as a light yellow liquid. 1H NMR (400 MHz, CDC13): (57.88-7.84 (m, 1H), 7.72-7.69 (m, 1H), 7.08-7.04 (m, 1H), 4.39 (q, J= 7.2 Hz, 2H), 1.39 (t, J= 7.2 Hz, 3H).
References:
WO2015/48301,2015,A1 Location in patent:Paragraph 00406
1072-85-1
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334792-76-6
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$125.00/1g