ChemicalBook CAS DataBase List 3-Bromo-2-cyanopyridine

3-Bromo-2-cyanopyridine synthesis

7synthesis methods

Product Name:3-Bromo-2-cyanopyridine
CAS Number:55758-02-6
Molecular formula:C6H3BrN2
Molecular Weight:183.01

3-Bromo-2-cyanopyridine can be used as organic intermediate and pharmaceutical intermediate, mainly in laboratory research and development process. It can be synthesized by the substitution reaction of 3-Bromopyridine Oxid and Trimethylsilyl cyanide.

2402-97-3
125 suppliers
$30.00/1 g

7677-24-9 Synthesis

7677-24-9
393 suppliers
$19.00/5g

55758-02-6
274 suppliers
$6.00/1g

Yield:55758-02-6 89%

Reaction Conditions:

with triethylamine in acetonitrile at 75; for 15 h;Inert atmosphere;

Steps:

1.1; 2.1; 3.1; 4.1; 5.1; 6.1
Dissolve 3-bromopyridine-N-oxide (19.2g, 110.4mmol, 1eq.) in 280ml acetonitrile, under the protection of nitrogen,Trimethylsilyl cyanide (32.9g, 331.2mmol, 3eq.) and triethylamine (22.3g, 220.8mmol, 2eq.) were sequentially added, and reacted at 75°C for 15 hours.After the reaction is over, after the reaction liquid is cooled, the reaction liquid is added to a saturated sodium bicarbonate solution in ice.Extract with ethyl acetate, wash the organic phase with saturated sodium chloride, and then dry,Purified by column chromatography to obtain 18 g of white solid 3-bromo-2-cyanopyridine with a yield of 89%.

References:

Ali Biological New Materials (Changzhou) Co., Ltd.;Shi Jianyun;Liu Chao;Dai Hongsheng;Gu Yunlong;Jiang Yunqing CN111285798, 2020, A Location in patent:Paragraph 0028-0029; 0032-0033; 0066-0067; 0070-0071

FullText

626-55-1 Synthesis