3-AMINO-N-METHYLPYRAZINE-2-CARBOXAMIDE synthesis

3synthesis methods

Product Name:3-AMINO-N-METHYLPYRAZINE-2-CARBOXAMIDE
CAS Number:36204-76-9
Molecular formula:C6H8N4O
Molecular Weight:152.15

5424-01-1
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593-51-1 Synthesis

593-51-1
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36204-76-9
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Yield:-

Reaction Conditions:

with benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide at 20; for 48 h;

Steps:

91

Example 91; 7V-Methyl-3-(2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyridin-4-ylamino)pyrazine-2-carboxamide; 3-Amino-λ'-methylpyrazine-2-carboxamide; A mixture of 3-aminopyrazine-2-carboxylic acid (965 mg, 6.94 mmol), methylamine hydrochloride (697 mg, 10.3 mmol), EDCI (1.61 g, 8.4 mmol), HOBt (1.136 g, 8.4 mmol) and DIEA (2.42 mL, 13.9 mmol) in DMF (24 mL) was stirred at room temperature for 48 h. It was diluted with ethyl acetate and washed with saturated sodium bicarbonate, brine and dried over magnesium sulfate. The solvent was removed and the residue was purified by silica gel chromatography (combiflash- companion; DCM/MeOH gradient) to give the title compound.

References:

WO2008/115369,2008,A2 Location in patent:Page/Page column 132-133

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$10.00/5g

74-89-5 Synthesis