ChemicalBook CAS DataBase List 3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride

3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride synthesis

5synthesis methods

Product Name:3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride
CAS Number:63971-25-5
Molecular formula:C12H21NO
Molecular Weight:195.3

41100-52-1 Synthesis

41100-52-1
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3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride

63971-25-5
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$47.00/50 mg

Yield: 4.4 g

Reaction Conditions:

with sulfuric acid;nitric acid at 20; for 39 h;Cooling with ice;

Steps:

1; 2
Under ice bath conditions, 6.1 mL of concentrated nitric acid and 61.0 mL of concentrated sulfuric acid were added to the reaction flask, and stirred and activated for about 4 h. Then, 6.1g of intermediate II was added in portions, and after continuing the reaction for 3h, the ice bath was removed. The reaction was carried out at room temperature for about 36 hours. Ice water was added to the reaction solution and stirring was continued for about 30 minutes. Potassium hydroxide was added in portions to adjust the pH to greater than 12, and stirring was continued for about 2 hours. After filtration, the filter cake was washed with dichloromethane, the filtrate was separated, the organic phase was concentrated, and separated by column chromatography to obtain about 4.4g of intermediate III.

References:

Sichuan Shangrui Bio-pharmaceutical Co., Ltd.;Liu Chao;Ye Zizheng;Peng Xianfeng;Dai Ping CN111233670, 2020, A Location in patent:Paragraph 0040-0041; 0044; 0047; 0050

707-37-9 Synthesis