3-AMINO-2-HYDROXY-N,N-DIMETHYLBENZAMIDE synthesis
- Product Name:3-AMINO-2-HYDROXY-N,N-DIMETHYLBENZAMIDE
- CAS Number:464913-11-9
- Molecular formula:C9H12N2O2
- Molecular Weight:180.2
66952-65-6
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464913-11-9
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Yield:464913-11-9 100%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethanol; under 1500.15 Torr;
Steps:
1.7 3-Amino-2-hydroxy-N,N-dimethylbenzamide
Step 7
3-Amino-2-hydroxy-N,N-dimethylbenzamide
A solution of 33.5 g of 2-hydroxy-N,N-dimethyl-3-nitrobenzamide in 600 ml of ethanol was added to a suspension of 3.35 g of Pd/C 10% in 70 ml of ethanol.
The reaction medium was stirred under 2 bar of hydrogen overnight. TLC and HPLC control (t=0.66 M+181).
The reaction medium was filtered through celite and the filtrate was evaporated.
29 g of 3-amino-2-hydroxy-N,N-dimethylbenzamide were obtained in the form of an oily brown solid. Yield=100%.
References:
US2014/296254,2014,A1 Location in patent:Paragraph 0102
473731-67-8
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85-38-1
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35748-36-8
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