3,6-Dichloropyridazine-4-carboxylic acid synthesis
- Product Name:3,6-Dichloropyridazine-4-carboxylic acid
- CAS Number:51149-08-7
- Molecular formula:C5H2Cl2N2O2
- Molecular Weight:192.99
19064-64-3
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51149-08-7
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Yield:-
Reaction Conditions:
with potassium chromate;sulfuric acid at 40; for 2 h;
Steps:
41.a Example 41; 6- (4-HYDROXY-3-METHOXY-PHENYL)-3-OXO-2, 3-DIHYDRO-PYRIDAZINE-4- carboxylic acid 4-chloro-benzyl amide; a) 3, 6-Dichloro-pyridazine-4-carboxylic acid
A solution of 24.9 G 3, 6-dichloro-4-methylpyridazine and 56,7 g potassium dichromate in 250 ml of concentrated sulphuric acid are stirred at 40°C for 2 h, the reaction mixture is poured onto 1.5 1 ice-water and extracted with ethyl acetate. The organic layer is extracted with water and a saturated solution of NACI, dried over MGS04 and evaporated. The raw product is used without any further purification. Yield : 27.1 G MS: M+1 =193. 1
References:
WO2004/46117,2004,A1 Location in patent:Page 110
19064-64-3
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$6.00/5g
51149-08-7
233 suppliers
$6.00/1g
50681-26-0
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$45.00/25mg
5754-18-7
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$14.00/1g
51149-08-7
233 suppliers
$6.00/1g
616-02-4
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51149-08-7
233 suppliers
$6.00/1g