3,6-DIBROMO-2,7-DIHYDROXYNAPHTHALENE synthesis
- Product Name:3,6-DIBROMO-2,7-DIHYDROXYNAPHTHALENE
- CAS Number:96965-79-6
- Molecular formula:C10H6Br2O2
- Molecular Weight:317.96
582-17-2
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Yield: 91%
Reaction Conditions:
with tin;bromine in water;acetic acidReflux;
Steps:
Step 1. Bromination
Bromine (5.5 mL, 109 mmol) dissolved in acetic acid (40 mL) was added dropwise over a 20 min period to a stirred solution of 2,7-dihydroxynaphthalene (S1, 5 g, 31 mmol) dissolved in acetic acid (115 mL). The mixture was diluted with water (3 mL) and brought to reflux. Upon discoloration of bromine, powdered tin (7.6 g, 56 mmol) was added drop by drop. The mixture was allowed to reflux for a further 6 h, then cool down to RT, and diluted with water (50 mL), the precipitated product was filtered as a colourless solid, which was recrystallized from AcOH to give 3 (9 g, 91%).
References:
Park, Min Sung;Kim, Gilhoon;Won, Hoshik;Han, Jin Wook;Oh, Chang Ho [Bulletin of the Korean Chemical Society,2020,vol. 41,# 1,p. 88 - 91] Location in patent:supporting information
98994-89-9
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96965-79-6
71 suppliers
$30.00/250mg