3,5-Dichlorophenol synthesis
- Product Name:3,5-Dichlorophenol
- CAS Number:591-35-5
- Molecular formula:C6H4Cl2O
- Molecular Weight:163
![Benzene, 1,3-dichloro-5-[2-(trimethylsilyl)ethoxy]-](/CAS/20210305/GIF/1338215-37-4.gif)
1338215-37-4
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591-35-5
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Yield:591-35-5 87%
Reaction Conditions:
Stage #1: [2-(3,5-dichlorophenoxy)ethyl]trimethylsilanewith cesium fluoride in N,N-dimethyl-formamide at 60; for 1 h;Inert atmosphere;
Stage #2: with water in N,N-dimethyl-formamide;Inert atmosphere;
Steps:
Procedure of trimethyl silane cleavage
General procedure: To a solution of [2-(phenoxy)-ethyl]-trimethyl-silane (Table-3, entry-1) (195mg, 1.0 mmol) in dry DMF (2 ml) was added cesium fluoride (576 mg, 3.0 mmol) and heated at 60°C for 1 h. Reaction mass was diluted with water and extracted with ethyl acetate (3 x 20 ml). The combined organic layer was washed with water, brine solution, dried over anhydrous sodium sulphate and concentrated under reduce pressure to give phenol 92mg (93% yield). Phenols of Table-3 are commercially available from Aldrich and its identity was confirmed by comparison of 1H NMR data with authentic sample.
References:
Dibakar, Mullick;Prakash, Anjanappa;Selvakumar, Kumaravel;Ruckmani, Kandasamy;Sivakumar, Manickam [Tetrahedron Letters,2011,vol. 52,# 41,p. 5338 - 5341] Location in patent:supporting information; experimental part
67492-50-6
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591-35-5
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68716-51-8
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591-35-5
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33719-74-3
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591-35-5
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33719-74-3
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591-35-5
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65262-96-6
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7051-16-3
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