3,4-Dibenzyloxybenzaldehyde synthesis
- Product Name:3,4-Dibenzyloxybenzaldehyde
- CAS Number:5447-02-9
- Molecular formula:C21H18O3
- Molecular Weight:318.37
Yield:5447-02-9 96%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20 - 130; for 4 h;
Steps:
1.1 (1) Synthesis of 3,4-dibenzyloxybenzaldehyde:
55.2 g (0.40 mol) of protocatechualdehyde was dissolved in 600 mLN, N-dimethylformamide,116.0 g (0.92 mol) of benzyl chloride was slowly added,Anhydrous K2CO3165.6 g (1.2 mol) was weighed and added thereto,The reaction was stirred at room temperature for 2 hours,Further, 35.2 g (0.40 mol) of K2CO3,130 heated for 2 hours,Cooled to room temperature,Filtration,The filtrate was added to ice water,Acidified with dilute hydrochloric acid,Yielding a yellow precipitate,Filtration,Washed with ice water,Yielding 122.1 g of 3,4-dibenzyloxybenzaldehyde in 96% yield.
References:
Northwestern University;Xi'an Shiyou University;Zheng, Xiaohui;Bai, Yajun;Zhang, Qunzheng;Nan, Yefei;Qin, Fanggang;Liu, Pei;Fang, Jiacheng CN104030923, 2016, B Location in patent:Paragraph 0030; 0058; 0059; 0060
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