3,3-DIFLUORO-1,5-PENTANEDIOL synthesis

7synthesis methods

Product Name:3,3-DIFLUORO-1,5-PENTANEDIOL
CAS Number:126300-39-8
Molecular formula:C5H10F2O2
Molecular Weight:140.13

Benzene, 1,1'-[(3,3-difluoro-1,5-pentanediyl)bis(oxymethylene)]bis-

126300-41-2
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126300-39-8
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Yield:126300-39-8 98.1%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen;glacial acetic acid in methanol;lithium hydroxide monohydrate at 25; for 20 h;

Steps:

1.4; 2.4 Step (4)

to a 250 mL round-bottom flask, add 3.60 g of compound 4a (11.24 mmol, 1.00 eq), methanol (54 mL), and acetic acid (0.72 g). After nitrogen displacement, a Pd/C catalyst (10% Pd, containing 55% water) (1.2 g) was added, followed by hydrogen substitution, and atmospheric hydrogenation at 25 °C for 20 h. Add 2 g of activated charcoal, stir, filter and wash the cake with 20 mL of methanol. Concentrated under reduced pressure, dried in vacuum, colorless oil 5 (1.55 g, yield 98.1%).

References:

CN114539020,2022,A Location in patent:Paragraph 0048; 0050; 0052; 0054

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References

1,3-Dithiolane-2,2-diacetic acid, 2,2-diethyl ester

126300-42-3
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126300-39-8
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References

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126300-39-8
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References

1,3-Dithiolane, 2,2-bis[2-(phenylmethoxy)ethyl]-

126300-40-1
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126300-39-8
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References