ChemicalBook CAS DataBase List 3-(2-ETHOXYPHENYL)PROPIONIC ACID

3-(2-ETHOXYPHENYL)PROPIONIC ACID synthesis

5synthesis methods

Product Name:3-(2-ETHOXYPHENYL)PROPIONIC ACID
CAS Number:220285-28-9
Molecular formula:C11H14O3
Molecular Weight:194.23

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Yield:220285-28-9 67%

Reaction Conditions:

with potassium hydroxide in methanol at 60; for 16 h;Inert atmosphere;

Steps:

3-(2-Ethoxyphenyl)propionic acid (S18a)

A solution of methyl 3-(2-ethoxyphenyl)propionate (210 mg, 1.01 mmol) in methanolic KOH (1.0 M, 5.0 mL, 5.0 mmol) was heated at 60 °C for 16 h. The solvent was removed and the residue was diluted with water and acidified (pH 3) with 10% aqueous HCl to obtain a precipitate. The precipitate was collected, washed with water, and dried to yield 150 mg (76%) of product as a white powder.

References:

Williams, John D.;Khan, Atiyya R.;Cardinale, Steven C.;Butler, Michelle M.;Bowlin, Terry L.;Peet, Norton P. [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 1,p. 419 - 434] Location in patent:supporting information