ChemicalBook CAS DataBase List (2R)-2-formamido-4-(methylsulfanyl)butanoic acid

(2R)-2-formamido-4-(methylsulfanyl)butanoic acid synthesis

4synthesis methods

Product Name:(2R)-2-formamido-4-(methylsulfanyl)butanoic acid
CAS Number:44978-50-9
Molecular formula:C6H11NO3S
Molecular Weight:177.22

348-67-4 Synthesis

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(2R)-2-formamido-4-(methylsulfanyl)butanoic acid

44978-50-9
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Yield:-

Reaction Conditions:

in formic acid at 20; for 4 h;Cooling with ice;

Steps:

1.a Step a) Preparation of N-Formyl-D-Methionine

Step a) Preparation of N-Formyl-D-Methionine
D-Methionine (3g, 200mmol) was added into a solution of 1 1 ml_ of acetic anhydride and 4.5 ml_ of formic acid cooled in an ice-water bath. The mixture was stirred at room temperature for 4 hours, then the reaction solution was quenched with methanol and concentrated to provide the product which was used in the next step without purification.

References:

WO2015/164289,2015,A1 Location in patent:Page/Page column 63; 64