4,5-dichloro-2-[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one synthesis
- Product Name:4,5-dichloro-2-[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one
- CAS Number:26806-47-3
- Molecular formula:C11H5Cl2F3N2O
- Molecular Weight:309.07
766-40-5
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98-16-8
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26806-47-3
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$130.00/250mg
Yield:-
Reaction Conditions:
Stage #1: 3-trifluoromethylanilinewith hydrogenchloride;sodium nitrite in water at -5 - 0; for 0.5 h;
Stage #2: with hydrogenchloride;tin(ll) chloride in water at 0; for 2 h;
Stage #3: Mucochloric acid in water at 80 - 90;
References:
Zhang, Ji;Morton, Howard E.;Ji, Jianguo [Tetrahedron Letters,2006,vol. 47,# 49,p. 8733 - 8735]