6-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid synthesis

2synthesis methods

Product Name:6-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid
CAS Number:24796-59-6
Molecular formula:C10H6ClNO3
Molecular Weight:223.61

Ethyl 6-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylate

7545-52-0
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$39.00/1mg

6-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid

24796-59-6
14 suppliers
$90.00/50mg

Yield:24796-59-6 47%

Reaction Conditions:

Stage #1: methyl 6-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylatewith lithium hydroxide monohydrate;sodium hydroxide in tetrahydrofuran; for 16 h;
Stage #2: with aqueous citric acid in tetrahydrofuran;lithium hydroxide monohydrate;

References:

Yoshikawa, Kenji;Kobayashi, Shozo;Nakamoto, Yumi;Haginoya, Noriyasu;Komoriya, Satoshi;Yoshino, Toshiharu;Nagata, Tsutomu;Mochizuki, Akiyoshi;Watanabe, Kengo;Suzuki, Makoto;Kanno, Hideyuki;Ohta, Toshiharu [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 24,p. 8221 - 8233] Location in patent:experimental part

2-Butenedioic acid, 2-[(4-chlorophenyl)amino]-, 1,4-dimethyl ester

87748-34-3
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24796-59-6
14 suppliers
$90.00/50mg

References