19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate synthesis

8synthesis methods

Product Name:19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate
CAS Number:2205-78-9
Molecular formula:C24H30O4
Molecular Weight:382.49

68-22-4 Synthesis

68-22-4
440 suppliers
$28.00/250mg

75-36-5 Synthesis

75-36-5
579 suppliers
$17.92/100G

19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate

2205-78-9
19 suppliers
$145.00/100mg

Yield:2205-78-9 110 kg

Reaction Conditions:

with pyridine;acetic anhydride at 20; for 6 h;Industrial scale;

Steps:

1.2.1 Acylation reaction

Step 1) 100kg norethindrone (II) obtained is added with 200kg acetic anhydride, 100kg pyridine, 120kg acetyl chloride is added dropwise at room temperature, and the reaction is stirred for 6 hours. TLC analysis of the raw material is complete, 1000kg water is added, centrifuged, dried to obtain acyl Compound (III) 110kg, mass yield 110%, detection HPLC ≥98%, single impurity ≤1.0%.

References:

CN110981930,2020,A Location in patent:Paragraph 0028-0029; 0032-0033

68-22-4 Synthesis

68-22-4
440 suppliers
$28.00/250mg

2205-78-9
19 suppliers
$145.00/100mg

References

111-87-5 Synthesis