BIS[BIS(3,5-DITRIFLUOROMETHYLPHENYL)PHOSPHINO]METHANE synthesis
- Product Name:BIS[BIS(3,5-DITRIFLUOROMETHYLPHENYL)PHOSPHINO]METHANE
- CAS Number:220185-39-7
- Molecular formula:C33H14F24P2
- Molecular Weight:928.37
28240-68-8
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328-70-1
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220185-39-7
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Yield:220185-39-7 66%
Reaction Conditions:
Stage #1: 3,6-bis(trifluoromethyl)bromobenzenewith isopropylmagnesium chloride in tetrahydrofuran at 0; for 3 h;Inert atmosphere;Glovebox;Schlenk technique;
Stage #2: methylenebis(dichlorophosphine) in tetrahydrofuran;diethyl ether at 0 - 20; for 12 h;Inert atmosphere;Glovebox;Schlenk technique;
References:
Hulley, Elliott B.;Welch, Kevin D.;Appel, Aaron M.;Dubois, Daniel L.;Bullock, R. Morris [Journal of the American Chemical Society,2013,vol. 135,# 32,p. 11736 - 11739] Location in patent:supporting information