tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate synthesis
- Product Name:tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate
- CAS Number:201162-53-0
- Molecular formula:C11H20N2O2
- Molecular Weight:212.29
![tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate](/CAS/GIF/201162-52-9.gif)
201162-52-9
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201162-53-0
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Yield:201162-53-0 100%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethanol; under 760.051 Torr; for 18 h;
Steps:
23.B 3,8-Diaza-bicyclo[3.2.1]octane-3-carboxylic Acid tert-butyl Ester
Example 23B 3,8-Diaza-bicyclo[3.2.1]octane-3-carboxylic Acid tert-butyl Ester A solution of the product of Example 23A (0.62 g. 0.12 mmol) in EtOH (10 mL) was stirred with Pd/C (Aldrich, 60 mg, 10 wt %) under 1 atmosphere of H2 (balloon) for 18 h. The mixture was filtered, concentrated and purified by column chromatography (SiO2, 1% NH4OH: 9% CH3OH: 90% CH2Cl2) to provide the title compound (0.44 g, 100% yield). MS (DCl/NH3) m/z 213 (M+H)+.
References:
US2005/101602,2005,A1 Location in patent:Page/Page column 35
![8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane](/CAS/GIF/93428-56-9.gif)
93428-56-9
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201162-53-0
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![1-Propanone, 1-[8-(phenylmethyl)-3,8-diazabicyclo[3.2.1]oct-3-yl]-](/CAS/20210305/GIF/98068-06-5.gif)
98068-06-5
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201162-53-0
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![3,8-Diazabicyclo[3.2.1]octane, 3-(1-oxopropyl)-](/CAS/20180531/GIF/67571-93-1.gif)
67571-93-1
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201162-53-0
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$18.00/100mg