2-tert-Butyl-4,6-dimethylphenol synthesis
- Product Name:2-tert-Butyl-4,6-dimethylphenol
- CAS Number:1879-09-0
- Molecular formula:C12H18O
- Molecular Weight:178.27
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Yield:1879-09-0 253 g (86.6%)
Reaction Conditions:
with toluene-4-sulfonic acid in toluene
Steps:
I 2,4-Dimethyl-6-t-butylphenol.
EXAMPLE I 2,4-Dimethyl-6-t-butylphenol. To a 1 liter flask equipped with a condenser, over-head stirrer, and gas inlet tube was added 2,4-dimethylphenol (200 g, 1.64 m.), toluene (400 ml), and p-toluenesulfonic acid (10 g). After heating this solution to reflux, isobutylene was added continuously for 14 hrs. Upon cooling, the solution was washed twice with water (400 ml), dried (MgSO4), and the solvent evaporated to afford a dark brown liquid. GC confirmed that this liquid was about 72% product. Distillation afforded 253 g (86.6%) of clear product which was shown to be 97% pure by GC.
References:
The B. F. Goodrich Company US4163008, 1979, A
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$31.00/25g