ChemicalBook CAS DataBase List 2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER synthesis

4synthesis methods

Product Name:2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER
CAS Number:660867-80-1
Molecular formula:C12H18BNO2
Molecular Weight:219.09

22282-99-1 Synthesis

22282-99-1
391 suppliers
$6.00/5g

73183-34-3
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$6.00/5g

2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

660867-80-1
160 suppliers
$11.00/250mg

Yield: 70%

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in 1,4-dioxane at 90; for 12 h;Inert atmosphere;Miyaura Borylation Reaction;

Steps:

4.3. General methods for intermediates 6 and 10
General procedure: To a solution of borate (1 equiv) and bipinacol borate (1.2 equiv)in anhydrous dioxane, KOAc (3 equiv) and Pd(dppf)Cl2 (0.05% mol)were added. After reaction at 90 C for 12 h under N2 atmosphere,the solvent was concentrated and water was added to the reactionflask, and then the filter cake was washed with petroleum etherand acetonitrile to obtain the intermediates 6 and 10.

References:

Chen, Huanhua;Ding, Huaiwei;Gao, Yaping;Jiang, Xiaowen;Liu, Wenjie;Liu, Wenwu;Liu, Xin;Tian, Liting;Xu, Zihua;Zhao, Qingchun [European Journal of Medicinal Chemistry,2021,vol. 222]