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6952-53-0

2-METHYLPROYL 2-PYRIDYL KETONE synthesis

3synthesis methods
-

Yield:6952-53-0 80%

Reaction Conditions:

Stage #1: 2-bromo-pyridinewith n-butyllithium in tetrahydrofuran;hexane at -78; for 0.25 h;Inert atmosphere;
Stage #2: N-methoxy-N,3-dimethylbutanamide in tetrahydrofuran;hexane at -78 - 20; for 1.5 h;Inert atmosphere;

References:

Kurian, Jais;Kannoth M, Muraleedharan [Organic and Biomolecular Chemistry,2019,vol. 17,# 39,p. 8832 - 8848]

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