Yield:260981-46-2 92%

Reaction Conditions:

with 1,1,1,3,3,3-hexamethyldisilazane potassium in toluene; for 1 h;Reflux;

Steps:

1.g

Preparation of 2-methyl-2-(4-methylpyridin-2-yl)propanenitrile; 2-Fluoro-4-methylpyridine (1.0 g, 9 mmol), KH(Si(CH₃)₃)₂, (27 mL, 13.5 mmol, 0.5 M solution in toluene) and 2-methylpropanenitrile (3.2 mL) were refluxed in toluene for 1 h. The reaction was quenched with saturated NH₄Cl, the organics separated, dried (MgSO₄), concentrated in-vacuo and the residue purified by column chromatography (20% EtOAc/pet ether) to give 2-methyl-2-(4-methylpyridin-2-yl)propanenitrile (1.22 g, 92%). MS m/z 161.4 (calc'd for C10H₁₂N₂).

References:

US2009/270394,2009,A1 Location in patent:Page/Page column 11-12