2-Fluoro-4-hydroxybenzonitrile synthesis
- Product Name:2-Fluoro-4-hydroxybenzonitrile
- CAS Number:82380-18-5
- Molecular formula:C7H4FNO
- Molecular Weight:137.11
105942-08-3
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82380-18-5
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Yield:82380-18-5 82%
Reaction Conditions:
with formic acid;oxygen;triethylamine;copper(ll) bromide in acetonitrile at 20; for 24 h;UV-irradiation;
Steps:
5 Example 5
4-Bromo-2-fluorobenzonitrile (0.25 mmol), copper bromide (0.03 mmol), triethylamine (0.25 mmol, 1.0 equiv), HCOOH (0.75 mmol, 3.0 equiv) at room temperature,179mmol of the reaction solvent CH3CN was added to the reaction tube, and the mixture was stirred at room temperature for 24 hours under the oxygen atmosphere.After the completion of the reaction was monitored by thin layer chromatography, 20 mL of water and 10 mL of ethyl acetate were added for extraction, followed by drying over anhydrous sodium sulfate, filtering after 5 minutes, washing the filter cake with ethyl acetate (5 mL×3 times), and then swirling off the solvent.The product was isolated by column chromatography (eluent: petroleum ether: ethyl acetate = 6:1), the product was a yellow liquid, yield 82%;
References:
CN107915586,2018,A Location in patent:Paragraph 0097-0100
3939-09-1
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82380-18-5
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94610-82-9
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$16.00/1g
82380-18-5
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348-27-6
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82380-18-5
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321-28-8
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$6.00/1g
82380-18-5
325 suppliers
$8.00/5g