2-Chloro-5-fluoropyrimidine synthesis
- Product Name:2-Chloro-5-fluoropyrimidine
- CAS Number:62802-42-0
- Molecular formula:C4H2ClFN2
- Molecular Weight:132.52
Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.
2927-71-1
421 suppliers
$6.00/5g
62802-42-0
320 suppliers
$12.00/5g
Yield:62802-42-0 50%
Reaction Conditions:
with acetic acid;zinc in tetrahydrofuran at 70; for 6 h;Heating / reflux;
Steps:
31.A
Step A: 2-Chloro-5-fluoropyrimidine To 2,4-dichloro-5-fluoropyrimidine (15.0 g, 89.8 mmol) is added tetrahydrofuran (100 mL) and zinc powder (17.6 g, 269 mmol). The mixture is heated to 70 0C with vigorous stirring, acetic acid (5.14 mL, 89.8 mmol) is added over Ih and the mixture is heated at reflux for an additional 5h. The mixture is diluted with dichloromethane, filtered
References:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG WO2007/106705, 2007, A1 Location in patent:Page/Page column 92-93
6693-08-9
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$26.00/100mg
62802-42-0
320 suppliers
$12.00/5g